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- Klotho is one of the essential proteins that function as neuroprotective, anti-apoptotic, and suppresses
- oxidative stress.
- Klotho has three protein forms, namely, a secretory, a cell membrane-associated, and an intracellular form. Membrane protease can digest the extracellular Klotho domain as soluble klotho and can be seen in CSF, urine, or blood. Secretory Klotho acts as paracrine, autocrine, or endocrine hormones in target cells.
- Secreted Klotho, A new Biomarker for Chronic Kidney research
- Klotho as secreted or soluble antiaging protein, whose protective activity is essential for a proper function of many organs.
- Standard range: 625-40000 pg/ml
- Sensitivity: 100 pg/ml
- Monoclonal Antibody Pair specific to human klotho secreted form only.
- Calibration: rh Secreted Klotho derived from CHO expression.
- Specificity: Human Secreted Klotho. Non cross-reactivity with Human Soluble Klotho alpha.
- Sample Type: serum, plasma,
- Size: 96 T
Citations of SK00708-06:
- Role of β-Klotho and Malondialdehyde in Metabolic Disorders, HIV Infection, and Antiretroviral Therapy (Maria Elena Gutiérrez-Pérez, et al. DNA and Cell Biology 2022 41:7, 691-698)
 
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Features
- Code No.: SK00708-06
Size: 96 T
Standard range: 625-40000 pg/ml
Sensitivity: 100 pg/ml
Specificity: human secreted Klotho or Klotho isoform 2 only
Sample type: plasma, serum
Intra-CV: 4-6%
Inter-CV: 8-10%
Data Sheet:PDF
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