CD209 serve as alternative receptors for S-RBD of SARS-CoV-2
Soluble CD209 / DC-SIGN is a C-type lectin receptor present on the surface of both macrophages and dendritic cells and involved in initiation of primary immune response.
A high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates.
The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells.
Acts as an attachment receptor for bacterial or virus pathogen antigens.