LOX-1, is an inflammation-induced receptor implicated in atherosclerotic plaque formation in acute coronary syndrome.
LOX-1 plays an important role to regulate cardiac remodeling and oxidative stress after ischemia-reperfusion.
Endothelial cells primarily express LOX-1 as receptor for ox-LDL.
ox-LDL has been shown to upregulate expression of LOX-1.
Size: 96 T
Sensitivity at 10 pg/mL
Monoclonal Antibody Pair Specific to the glycosylated human sLOX-1 (human cells)
Validated by WB & E
Calibrator: human soluble LOX-1 derived from HEK293
Citations Available
Citations:
Gabriele, M., Pucci, L., La Marca, M. et al. Cell Mol Biol Lett 21, 10 (2016) [cell cultures samples had been tested by Aviscera Bioscience LOX-1 ELISA Kit].
D. Kupczyk, et al, “Paraoxonase 1: The Lectin-Like Oxidized LDL Receptor Type I and Oxidative Stress in the Blood of Men with Type II Obesity,†Disease Markers, vol. 2019, Article ID 6178017, 7 pages, 2019.
Ozkan C, et al. Proprotein convertase subtilisin/kexin type 9 (PCSK9), soluble lectin-like oxidized LDL receptor 1 (sLOX-1) and ankle brachial index in patients with differentiated thyroid cancer. Endocr J. 2015;62(12):1091-9.
Features
Size: 96 T
Standard Range: 19.5 - 1250 pg/ml
Sensitivity: 10 pg/ml Specficity: human soluble LOX-1 HEK293 derived