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- Soluble Fibronectin type III Domain-Containing Protein 4 (FNDC4) is a secreted anti-inflammatory factor, upregulated in inflammatory bowel disease.
- The novel adipokine FNDC4 reduces lipogenesis and increases fat browning in human visceral adipocytes. (Frühbeck G, et al. FNDC4, a novel adipokine that reduces lipogenesis and promotes fat browning in human visceral adipocytes. Metabolism. 2020 Jul;108:154261)
- FNDC4 acts as an anti-inflammatory factor
New References of FNDC4 Research:
- Georgiadi A, et al. Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue. Nat Commun. 2021 May 20;12(1):2999
- Daudon M, Bigot Y, Dupont J, Price CA. Irisin and the fibronectin type III domain-containing family: structure, signaling and role in female reproduction. Reproduction. 2022 May 23;164(1):R1-R9
- Frühbeck G, et al., Rodríguez A. FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes. Cell Mol Immunol. 2021 Oct;18(10):2457-2459.
- FNDC4 Inhibits RANKL-Induced Osteoclast Formation by Suppressing NF-κB and CXCL10 Expression. Lv ZT et al. Biomed Res Int. 2018 May 30;2018:3936257.
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