Plasma levels of soluble endothelial protein C receptor (sEPCR), according to malaria clinical form and outcome. Bars represent median values. A, sEPCR levels in plasma specimens obtained at admission and at convalescence in patients with malaria, including 58 and 14, respectively, with cerebral malaria (CM); 77 and 25, respectively severe noncerebral malaria (SM); and 53 and 27, respectively, with uncomplicated malaria (UM). At admission, patients with CM had higher sEPCR levels than patients with SM or UM (P = .0001). The SM and UM groups had similar sEPCR levels (P = .5). B, Plasma sEPCR levels at admission in children with CM who survived versus those who died. For children who died, the mean sEPCR level was higher than that for survivors (P = .0003).
