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Growth differentiation factor 15 (GDF15; also known as MIC-1) is a divergent member of the TGF-β superfamily and is associated with body-weight regulation in humans and rodents.
Growth Differentiation Factor-15 is a reliable biomarker for heart failure.
Citations:
- Yang L, et al. GFRAL is the receptor for GDF15 and is required for the anti-obesity effects ofthe ligand. Nat Med. 2017 Aug 28. doi: 10.1038/nm.4394.
- Nandini Nair, and Enrique Gongora "Correlations of GDF-15 with sST2, MMPs, and worsening functional capacity in idiopathic dilated cardiomyopathy: Can we gain new insights into the pathophysiology?" J Circ Biomark. 2018 Jan 19;7:1849454417751735. doi: 10.1177/184945441775173
- Jörg Wischhusen, Ignacio Melero, Wolf Fridman. Growth/Differentiation Factor-15 (GDF-15): From
Biomarker to Novel Targetable Immune Checkpoint. Frontiers in Immunology, Frontiers, 2020, 11,
pp.951. ff10.3389/fimmu.2020.00951ff. ffhal-02878344f
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Features
Size: 96 T Standard Range: 15.6-1000 pg/ml Dynamic Range: 15.6-1000pg/ml Sensitivity: 3.9 pg/ml Sample Type: serum, EDTA plasma Sample Requires: 125 uL Dilution Factor: 2 Intra-CV: 4-8% Inter-CV: 8-12% Protocol: PDF
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